Drug description:

Clopamide is a piperidine and sulfamoylbenzamide derivative acts as an antidiuretic agent.
Clopamide is indicated for treatment of hypertension.
It is formulated as tablet for oral route of administration.

Mechanism of action:

Clopamide acts at the proximal convoluted tubule site of the nephron where it inhibits the sodium-chloride cotransporter. Clopamide selectively binds at the chloride binding site of the sodium chloride cotransporter in the PCT cells on the luminal side and thus interferes with the reabsorption of NaCl and thus causing an equiosmolar excretion of water along with NaCl.